Synaptic Facilitation and Behavioral Dishabituation in Aplysia: Dependence on Release of Ca from Postsynaptic Intracellular Stores, Postsynaptic Exocytosis, and Modulation of Postsynaptic AMPA Receptor Efficacy
نویسندگان
چکیده
Quan Li,1* Adam C. Roberts,2* and David L. Glanzman1,3 1Department of Physiological Science and 2Interdepartmental PhD Program in Molecular, Cellular, and Integrative Physiology, University of California Los Angeles, Los Angeles, California 90095-1606, and 3Department of Neurobiology and Brain Research Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095-1761
منابع مشابه
Synaptic facilitation and behavioral dishabituation in Aplysia: dependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy.
Sensitization and dishabituation of the defensive withdrawal reflex in Aplysia have been ascribed to presynaptic mechanisms, particularly presynaptic facilitation of transmission at sensorimotor synapses in the CNS of Aplysia. Here, we show that facilitation of sensorimotor synapses in cell culture during and after serotonin (5-HT) exposure depends on a rise in postsynaptic intracellular Ca(2+)...
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Synaptic plasticity and learning involve different mechanisms depending on the following: (1) the stage of plasticity and (2) the history of plasticity, or metaplasticity. However, little is known about how these two factors are related. We have addressed that question by examining mechanisms of synaptic plasticity during short-term and intermediate-term behavioral sensitization and dishabituat...
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تاریخ انتشار 2005